DOI: 10.1113/jphysiol.2013.255364
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These drugs have been affecting libido, as Dr Naveed Asif, a GP from London General Practice, explained: From a physical perspective, GLP-1 medications affect smooth muscle activity, which can influence arousability and orgasm due to changes in blood flow to the genital area
They'll say something like "take your dose as soon as you remember, unless it's almost time for your next dose." This is wrong for semaglutide because the risks are asymmetric: Late dose (taken 1 to 2 days after scheduled day): Blood levels drop slightly below target Appetite suppression weakens temporarily No increased side effect risk No safety concern Easy fix: take the dose when you remember, resume normal schedule Early dose (taken 1 to 2 days before scheduled day): Blood levels rise slightly above target Appetite suppression unchanged Modest increase in GI side effect risk Generally safe for one-time occurrence Risk increases if it becomes a pattern The standard advice to "take it when you remember" works fine for late doses
