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Patients were randomly assigned to one of three groups: (1) bipolar coagulation, (2) Epi-pledget, and (3) epinephrine with coagulation (Epi & Coagulation), at a 1:1:1 ratio using a random permuted-block algorithm and a comprehensive internet-based randomization service for clinical trials available at The surgeon was not involved in group allocation

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Data was extracted using a standardized form that included the following information: author, year and country of study, study design and population, key outcomes and results, main conclusions

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Free radicals can be harmful to the body because they may cause damage to our cells and DNA, a process called oxidative stress- similar to rusting