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The algorithm was developed by analyzing 11,981 IgG, 2341 IgE, and 403 IgA specific B-cell epitopes obtained from the IEDB, and it was observed that each class of antibody has unique features [61]

13a, Supplementary Table 9), suggesting that the distinct rotamer orientation of H296 ECL2 in Cagri-bound CTR (to accommodate the Glu linker) and/or the observed more open ECL3 conformation induced by the lipidated peptide may facilitate or stabilize an active CTR conformation (Supplementary Fig

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