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Moreover, MEK/ERK signal pathway activated by insulin, which can also be triggered by KRAS mutation, plays an essential role in PDA malignancy and invasion (Wang et al., 2019)
Importantly, no signals of drug-induced liver injury have emerged despite extensive real-world use, supporting the favorable hepatic safety profile of GLP-1 RAs [62]
By increasing GLP-1 production or stimulating its release, this approach can complement existing therapies, such as GLP-1RAs and DPP-4 inhibitors, offering additional benefits while potentially reducing side effects
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