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Glp1r and Gcg mRNA transcripts have been detected in RNA isolated from mouse skin and, using immunocytochemistry, the GLP-1R protein has been localised to regions of the epidermis adjacent to hair follicles [13]
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Higher doses do not necessarily produce greater safety risks if titration is slow and medical supervision is active
Contraindications: Not for use in individuals with cancer, those who are pregnant/breastfeeding, or anyone under 18 years of age
Most people experience peak nausea within the first 24 weeks, with substantial improvement by week 34 as their body tolerates the medication better
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