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Compounded semaglutide from licensed 503A pharmacies offers flexibility that prefilled pens cannot matchallowing dose increments, frequency adjustments, and even combination approaches

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Although preclinical data show promise (Loftis et al., 2013), their clinical applicability remains unclear owing to challenges, such as immune response variability and limited human trials

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Regarding collateral effects, the most commonly reported were gastrointestinal-related (diarrhea, nausea, vomiting, constipation) mainly occurring during the dose escalation period