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Glucagon-like peptide type 1 receptor agonistsIncretin effect and systemic effects of glucagon-like peptide type 1 and its agonists The incretin effect describes the phenomenon whereby oral glucose elicits higher (23 times) insulin secretory responses than does intravenous glucose.25 This is due to incretin hormones, such as GLP-1 or glucose-dependent insulinotropic polypeptide, which stimulate insulin secretion in response to food intake
Combination therapy was significantly associated with 0.68, 0.83, and 0.67 kg/m 2 greater reductions in BMI from baseline at 6, 12, and 18 months, respectively (See Supplementary Fig
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