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The molecular weight of PT-141 (1,025 Da) falls well within the optimal range for nasal delivery

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Z-D-Phe-Arg(HCl)-Trp-Lys( Boc)-NH 2 ( 7 ) 2 A solution of HCl in dioxane (17%, 50.3 mL as calculated from the acid-base titration of product 6 obtained from the previous step) was added dropwise to a stirred solution of protected dipeptide 6 (134.5 g, 295.3 mmol) in DMF (800 mL) at 7 C

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Davis, J

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Melanomas thicker than 4.0 mm have a significantly higher risk of metastasis of 40%.

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