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Animal Model and Ethics Statement Wistar rats from the breeding colony at the Universidade do Extremo Sul Catarinense (UNESC), Brazil, were housed four times per cage under controlled conditions of temperature (22 1 C), relative humidity (4555%) and light-dark cycle (12:12 p.m., light on at 6 a.m.)
Transdermal delivery presents a non-invasive alternative to oral and parenteral routes, allowing for controlled and sustained release of drugs while bypassing hepatic first-pass metabolism and minimizing systemic side effects
Afshar H, Roohafza H, Mohammad-Beigi H, et al
Decreases muscle damage by protecting the integrity of the muscle tissue, preserving the contractible function
(2018) 97:e11987
