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Efficacy and cardiovascular safety of DPP-4 inhibitors

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Thus, these data confirm that depletion of the level of RG (reduced glutathione) under hypoxic conditions plays a decisive role in reducing the level of the HIF-1 protein, and conversely, a high level of RG stabilizes the HIF-1 protein in ischemic conditions (Wang et al., 2012

By enhancing immune cell function, reshaping the tumor microenvironment, and boosting responses to immunotherapy, TMAO holds promise as a potential adjuvant to improve the efficacy of cancer immunotherapy

Modulates nitric oxide (NO) pathways , improving circulation and reducing oxidative stress