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It is currently prepared from pigs as a synthetic human form is not available
The literature on getting the molecule to the cellular level is thin
Dihexa, with its combined N-hexanoic-Tyr-Ile-(6) aminohexanoic amide structure, exhibited a significantly extended half-life of 335.5 9.5 min, confirming that both N- and C-terminal modifications are effective strategies for improving metabolic stability [2]
Data availability X-ray crystallographic data are available from the PDB under accession numbers 6U32 (reference), 7ZBA, 7ZBB and 7ZBD
Moreover, we demonstrated that a suite of commensal murine gut bacteria has higher MICs values for our novel compounds Metro-P3 and MF-01 compared with Metro (Supplementary Table 6)
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