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These brain regions are critical in the development of substance use disorders (SUDs), where addictive substances hijack natural reward pathways, leading to compulsive behaviors

Further electrophysiological study showed that, opposite to the effects on arcuate POMC neurons, GLP-1 hyperpolarizes arcuate NPY neurons indirectly via increased GABA A receptor-mediated neurotransmission of local GABAergic interneurons (Secher et al., 2014

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