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Since the liver is essential in regulating one-carbon metabolism and may influence the immunological responses in newborn animals, this organ may be an exciting objective for studying the fetal programming effects influenced by dietary methyl donors, such as Met

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BMJ Case Rep 2025;18(1):e263899

To understand the underlying mechanisms, inhibitors targeting the Notch pathway (DAPT) and NF-B pathway (BMS) were also applied to HUVEC and murine CLI models

Results At baseline, the mean body weight was 104.8 kg, the mean BMI was 38.0, and 94.5% of participants had a BMI of 30 or higher