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Fiber intake of 30-40 grams daily supports gut bacteria producing short-chain fatty acids that stimulate GLP-1 production

doi: 10.1080/14656566.2018.1509955 31 GrecoD

Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3- methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl] thiazolidine): A highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

Clinical superiority must be assessed through direct trials examining weight change, metabolic outcomes, adverse events, discontinuation rates and longer-term safety

The benefits fade gradually over time