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Understanding Dual Agonism: The Tirzepatide Mechanism GIP and GLP-1 Receptor Biology Glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 represent two key incretin hormones that regulate postprandial glucose homeostasis

The sequence encoding full-length human Pol (Met 1-Glu335) was cloned into the SalI/NotI restriction sites of the pGEXT43(TEV) vector 41

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