Tirzepatide, a once-weekly glucose-dependent insulinotropic polypeptide and GLP-1 receptor agonist induced substantial weight reduction in previous placebo-controlled trials in patients with type 2 diabetes and obesity, Rohit Loomba, MD, MHSc, chief of the division of gastroenterology and hepatology at University of California, San Diego, and director of the MASLD Research Center, said at EASL Congress
Affiliation: 1 Faculty of Medicine, Tbilisi State Medical University, Tbilisi 0186, Georgia Email: [email protected] ORCID: Affiliation: 1 Faculty of Medicine, Tbilisi State Medical University, Tbilisi 0186, Georgia ORCID: Affiliation: 1 Faculty of Medicine, Tbilisi State Medical University, Tbilisi 0186, Georgia ORCID: Affiliation: 2 American MD Program, Tbilisi State Medical University, Tbilisi 0186, Georgia ORCID: Affiliation: 1 Faculty of Medicine, Tbilisi State Medical University, Tbilisi 0186, Georgia ORCID: Explor Cardiol
PMID 19821334
It can also make it harder to manage blood sugar levels due to insulin resistance
The compound's ability to cross the blood-brain barrier made it particularly promising for central nervous system effects