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Tirzepatide is a once-weekly injectable medication approved by the FDA for chronic weight management in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbidity
Previous AngIV analogs, while showing promise in animal models of dementia, were hindered by poor metabolic stability indicated by a short half-life, and an inability to cross the BBB due to their peptide nature
sex-specific analyses have not been published, making definitive conclusions about safety in women premature
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Several studies showed a reduced recurrence rate with the use of synthetic meshes
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