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That's not true for everyone, but for most of us, it definitely is
Patients with persistent heartburn despite optimal PPI therapy or those with alarm symptoms (difficulty swallowing, weight loss, anemia) should be referred for endoscopic evaluation according to clinical guidelines
Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D
An increase warrants attention, especially if combined with symptoms like fatigue or abdominal discomfort
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