One randomized trial reported increases in body stores after six months, while other trials have shown mixed results, so the picture is still developing [1][2]
Jin L, Kimura S, Zhou Y, Kuroda J, Asou H, Inaba T, Milda T, Konopleva M, Andreeff M , Tabe Y
Silicon-containing nanomedicine and biomaterials: materials chemistry, multi-dimensional design, and biomedical application
This strategy is particularly promising when used in combination with immune checkpoint inhibitors, such as anti-PD-1/PD-L1 antibodies, which have shown success in some cancers but have inconsistent effectiveness in solid tumors because of the TMEs strong immunosuppressive properties [159]
Note: Some individuals may experience the skin temporary darkening before it gets lighter