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Here is the detail that matters for split dosing
J Neurol Sci (1993) 118(2):1817.10.1016/0022-510X(93)90108-B 43 ScholteHRBuschHFBakkerHDBogaardJMLuyt-HouwenIEKuytLP
However, these animal findings are concerning enough that drug manufacturers and regulatory agencies have recommended caution until we have better human data
(Marteau 2001) Image 4
The Pernicious Anaemia Society notes this is well documented but poorly understood, and that some patients self-inject more frequently
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