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The prior art also describes a synthesis method using Fmoc solid phase sequential one by one coupling, wherein Mmt, Mtt, Dde, or ivDde protecting group is selected for temporary orthogonal protection when an amino acid is coupled to the side chain of the lysine, and then a certain method is selected for removing the protecting groups, allowing to couple on the side chain in sequence
Both medications belong to the GLP-1 receptor agonist class and work by affecting the digestive system in similar ways
The article lists the clinical goal as its own dosing consideration, noting that the objective may be weight loss, glucose control, appetite suppression, or cardiovascular benefit, and that each informs the strategy differently
Ozempic face refers to facial hollowing and skin sagging that can occur with rapid weight loss on GLP-1 medications, often linked to the loss of fat and muscle beneath the skin