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Readers Share Thoughts: Kathy responded with this observation: A high B12 reading could indicate a methylation issue which causes the B12 to pool in ones system because it can not be broken down and used properly
However, you may see results sooner when you maintain proper diet and exercise
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Crucially, the community feedback is inconsistent a meaningful share of reports describe no noticeable effect at all in the first week, and a subset describe early adverse effects (headache, brain fog, irritability) rather than benefit
Skin penetration represents the primary challenge
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