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An IV glucose tolerance test ( 54 ) was used to group rats according to the glucose tolerance before treatment (at day 1)

The most commonly reported sensation is early satiety feeling full after eating much smaller portions than usual

uptake of cystine through system x c (xCT and CD98) and subsequent reduction by thioredoxin reductase (TXNRD1)

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Higher doses may produce more dramatic shifts in muscle glucose handling, leading to symptoms during the adjustment period