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Alongside weight loss, participants showed modest reductions in systolic blood pressure across dose groups, with mean reductions in the range of approximately 46 mmHg in higher-dose cohorts, though values varied by dose and should be interpreted cautiously given the trial's size
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Structures of full-length class B receptors were determined in complex with their orthosteric agonist peptides, however, little is known about their extracellular domain (ECD) conformations in the absence of orthosteric ligands, which has limited our understanding of their activation mechanism
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