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GHK-Cu research in aged mice showed improved cognitive performance in maze tests after just three weeks of treatment, with evidence of decreased brain inflammation and epigenetic pathway activation

User experimentation suggests that longer initial treatment periods (6+ months continuous) support better benefit retention during subsequent breaks, complete discontinuation breaks of 1-2 months show acceptable benefit maintenance for most users, and very extended breaks (3-6+ months) increase risk of regression toward pre-treatment baseline particularly for short initial treatment courses