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Cold Sensitivity as a Side Effect: What Clinical Trials Show Large randomized trials of tirzepatide (SURMOUNT-1, SURMOUNT-2, and SURMOUNT-3) documented gastrointestinal side effects like nausea and vomiting most frequently, but cold sensitivity did not appear in the primary adverse event lists
Tirzepatide (Mounjaro, Zepbound) is linked to a 20 percent reduction
GLP-1 RAs may also improve liver function, this effect is thought to involve activation of AMP-activated protein kinase (AMPK), a key metabolic regulator that inhibits fatty acid synthesis and promotes fatty acid -oxidation, leading to decreased lipid accumulation in hepatocytes 22,23,24,25
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