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NNMT Pathway Research Context Nicotinamide + SAM NNMT substrates NNMT Methyl-transfer enzyme targeted by 5-Amino-1MQ 1-MNA + SAH Reaction products Research interpretation: NNMT inhibition is studied for how reduced nicotinamide methylation may alter 1-MNA formation, nicotinamide partitioning, NAD + -salvage-related measurements, and cellular methyl-economy markers

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This system rated cartilage structural integrity from 0, defined as normal to 6, defined as complete disorganization, and assessed cellularity from 0, defined as normal, to 3, defined as hypocellularity, for a total possible score of 0 to 9