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Early studies in obese individuals showed some reductions in body fat mass, but findings are not consistent across trials: In one clinical trial, AOD9604 did not demonstrate statistically significant weight loss compared to placebo, suggesting its fat-burning effects may be modest without lifestyle intervention (summary of trials)
Studies of copper transport and homeostasis : This includes work showing that GHKCu can compete with albumin for copper binding and facilitate cellular copper uptake in a nontoxic form
Further work by Iwata et al
What I wont recommend: stacking MOTS-C with Ibutamoren or other oral GH secretagogues purely for fat loss
Key pathways such as c-MET and TGF-, modulated by factors like MACC1, are central to this process
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