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Therapeutic strategies aimed at restoring the CTSBCTSL balance or promoting CTSL maturation may help mitigate pathological trypsin activation and reduce pancreatitis severity

Dehydration can also worsen common tirzepatide side effects like constipation, which may indirectly affect appetite regulation

Administration protocols vary widely by research application researchers should consult published literature for context-specific guidance

In return, EraCal will receive upfront, development and commercial milestones of potentially $255 million, and royalties on sales if the drug reaches the market

After filtering for quality, 36 studies met inclusion criteria for detailed analysis