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PMID: 72 OlbrichHKridinKZirpelHHernandezGSadikCDGaffalEet al

That means: It is not FDA approved for general human use outside clinical trials

Rasmussen J, Duno M, Lund AM, Steuerwald U, Hansen SH, Joensen HD, et al

Which means at least 30 minutes before a meal or 2 hours after

The constipation mechanism is fundamentally the same across all of them, though the severity can vary based on dose, individual biology, and which specific side effect profile you experience

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