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Key factors include baseline body weight, adherence to reduced-calorie diet and increased physical activity, presence of type 2 diabetes (which typically results in less weight loss), concurrent medications affecting appetite or metabolism, and individual tolerance to gastrointestinal side effects

Sources Government of Ontario

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The maximum semaglutide dose for weight management is 2.4 mg weekly (Wegovy dosing)

Orforglipron is under assessment for the management of obesity and T2D and may provide a competitive alternative to oral semaglutide, with less burdensome administration, as it does not require to be taken at a fasting state [24]