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Gene expression studies using microarray analysis reported that GHK-Cu at low nanomolar concentrations influenced the expression of over 4,000 human genes in fibroblast models, including upregulation of collagen I, collagen III, and elastin synthesis, and modulation of matrix metalloproteinase activity (Pickart and Margolina, Symmetry 2018)

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This is proven in trials looking at long-term results of GLP-1 medicines on nicotine addiction