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171 Notably, DON showed the ability to significantly inhibit the generation and recruitment of MDSCs and to reprogram M2-like TAMs into proinflammatory TAMs, which increased tumor antigen cross-presentation to T cells and enhanced the efficacy of immune checkpoint blockade (ICB)

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Additionally, nitrites may participate in direct nitration reactions that modify thiol groups and amines in bacterial proteins, further compromising cellular function 15