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Patients Inadequately Controlled on Basal Insulin GetGoal-L-Asia randomised 311 patients with long-duration diabetes (mean 13.9 years) who were inadequately controlled on basal insulin to lixisenatide 20 g OD ( n = 154), or placebo ( n = 157) for 24 weeks [14]
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The antizyme proteins interact with ODC1 monomers preventing formation of functional homodimers while simultaneously altering the conformation of the monomers so that they are recognized by the proteasome
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