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This effect is particularly important in heart failure models, where fibrosis reduces cardiac elasticity and contractile ability (Zhang et al., 2021)

External resources PMC: The physiology of weight loss plateaus during obesity pharmacotherapy , a comprehensive analysis of metabolic adaptation mechanisms during GLP-1 receptor agonist therapy, including appetite feedback coefficients and energy expenditure changes

Systematic literature review shows that appetite rating does not predict energy intake

These are tiny sample sizes by medical research standards