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Common Adverse Events Researchers Track in Phase 2 and Phase 3 Across retatrutide side effects clinical trials queries, the same adverse-event cluster appears repeatedly: nausea, vomiting, diarrhea, constipation, decreased appetite, abdominal pain, back pain, and fatigue or tiredness

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249,250 Relevant studies suggest that the expression of GLP-1R on -cells is crucial for GLP-1s regulation of somatostatin secretion and the overall inhibitory effect on glucagon