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Although preclinical models have yielded promising resultsfor example, the histone deacetylase inhibitor WW437 and the RNA helicase EIF4A inhibitor Zotatifinthese findings have not yet translated effectively into clinical application, largely due to species-specific differences between human and animal models, as well as a lack of robust clinical data [356, 357]

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PYCNOGENOL is a natural extract originating from the bark of the maritime pine tree that grows along the coast of southwestern France

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