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Low GSH, neutrophil infiltration, myeloperoxidase activity and inflammation increase oxidative stress overwhelming the antioxidant defense, and hypochlorous acid mediated GSH oxidation and its attachment to proteins contribute to further GSH deficiency (114)
Compound 102 exhibited GPX4 activating effects in a concentration-dependent manner ( Figure 3 and Supplementary Figure S3 ), with both increased ratio of 5-HETE and LTB 4 and increased concentrations of 12-HETE and 15-HETE
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Ivy Shi, who is a resident in internal medicine at BIDMC, worked with Kazi to produce the analysis
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