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But we didnt stop there
GSH is synthesized from cysteine, glutamate, and glycine by the ATP-dependent enzyme -glutamyl-cysteine (-GC) ligase (GCL) synthetase, which is composed of the -GC ligase catalytic subunit (GCLC), the -GC modifier subunit (GCLM), and GSH synthetase (GSS) 24
In the low-overdose patient (A), the maximum number of necrosed cells was 46 out of 5,114 (0.89%) without zonation and increased to 52 upon applying 50% zonation (see Figure 4)
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