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Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults With Overweight or Obesity: The STEP 3 Randomized Clinical Trial

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Most people need 412 weeks at a therapeutic dose before experiencing meaningful symptom relief

Key questions to discuss with your team: What medical goals are you targeting, and how will we measure them beyond weight

From a translational standpoint, catestatin may be more tractable as a pathway biomarker or as a guide for targeting autonomic dysregulation rather than as a direct peptide therapeutic