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While these specific proteins were not significantly elevated in the sibling validation cohort, computational predictions based on (s)PLS-DA analysis did identify proteins associated with immunity and inflammatory responses such as Zinc-alpha-2-glycoprotein (AZGP1) and Carboxypeptidase B2 (CPB2) as being important contributors to group separation 48,49,50
A large preclinical toxicity program run across mice, rats, rabbits, and dogs found BPC-157 well tolerated with no serious treatment-related toxicity, no identifiable lethal dose, and no genotoxic or teratogenic signal, which is the strongest safety data point available by Xu 2020
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