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A 2025 mechanistic review published in The Journal of Clinical Endocrinology and Metabolism showed that tirzepatide, which activates the GIP receptor, showed less BMD loss than expected for the weight loss achieved

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Disclaimer: This article was prepared by Jenna Ogilvie, Ogilvie Editorial, and reviewed by Alex Azar , Jaime Almandoz, Govind Persad, Jeffrey Singer, and Tracy Zvenyach