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A 2025 study in the American Journal of Ophthalmology did not find a significant increase in NAION or ischemic optic neuropathy risk in patients taking semaglutide or GLP-1 medications compared with diabetes or high-BMI control groups
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All cited studies are conducted in cellular or rodent systems consistent with RUO classification
In practice some people notice a faster onset at the 4mg step than they did at 2mg because of that carry-forward
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