Double chins, or fat under the chin, seem to be more due to genetic predisposition than to overall body fat percentage or weight of an individual
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Chemogenetic activation of Gipr -expressing neurones in either the hypothalamus or hindbrain decreases food intake in mice, suggesting more than one centrally located population of GIPR neurons regulate appetite 7,8
Tissue-Level Interpretation Changes in body weight or adipose mass can result from altered food intake, hydration, lean mass, lipid synthesis, lipid mobilization, substrate oxidation, activity, thermogenesis, gastrointestinal effects, or tissue-specific adaptation
Kosiborod MN, Deanfield J, Pratley R, Borlaug BA, Butler J, Davies MJ, et al