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The rectal administration of glutathione may provide a more direct route for the medication to enter the systemic circulation, potentially leading to better bioavailability and efficacy

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The impact of hypoxia on cytosolic NADP redox dynamics has remained less clear since lack of oxygen as an electron sink causes metabolic reduction but also boosts H 2 O 2 production and glutathione oxidation in different phases of the hypoxic episode 41

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