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7b, c and Supplementary Fig

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Biomarker-Guided Therapy: Validating bronchoalveolar lavage fluid (BALF) levels of 4-HNE or plasma MDA as predictive markers for disease progression and acute exacerbations could enable patient stratification and personalized therapeutic interventions

MRI revealed symmetrical white matter lesions in the corticospinal tract (Wolters et al., 1982), while diffusion tensor imaging highlighted impaired white matter connectivity due to myelin damage rather than axonal injury ( Heroin also induces psychiatric symptoms, such as depression, anxiety, impulsiveness, and interpersonal sensitivity (Pasternak, 2012)