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The so-called incretin effect describes this phenomenon and also explains that orally ingested glucose leads to a higher insulin response than intravenously administered glucose leading to isoglycemic glucose excursions compared to oral glucose ( There are, however, challenges and limitations regarding therapy with GLP-1RA

Ricks told CNBC Wednesday that Lilly had held off on advertising Zepbound and launching the drug internationally in order to boost inventory in the U.S.: We havent been stimulating demand the way we had originally planned. Yet on the earnings call, Ricks maintained that underlying growth for the drugs was as strong as we would have hoped. Ricks asserted that Lilly management did not view the gap between the Q3 results and the projections of even higher growth as indicating a softening of demand for the GLP-1 drugs: Demand for Mounjaro and Zepbound has been strong and continues to grow as we expand both access and supply. Johnson denied that competition from compounders had a huge financial impact on Lillys business

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