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Building on this, Ward and colleagues also showed that mutation of other solvent-exposed amino acids surrounding I253 in mouse IgG1 could result in enhanced affinity at pH 6.0 towards a truncated soluble form of mouse FcRn as measured by surface plasmon resonance (SPR), resulting in increased serum persistence in WT mice [99]
Palaniyappan L, Crow TJ, Hough M, Voets NL, Liddle PF, James S, et al
The development of diabetes and obesity is underpinned by chronic inflammation [143]
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