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FIGURE 1 3 A unifying framework: the determinants of CUL5s context-dependent functions As the scaffold protein of the CRL5 complex (35), CUL5 intrinsically lacks substrate specificity
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During breakthrough infection after vaccination, T-cell and plasmablast activation occur rapidly, while nAb and memory B-cell activation occurs ~2 weeks postinfection
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After verifying the cytocompatibility, live HeLa cells are incubated with TPE-DCV (500 nM) for 5 min following the standard cell-staining protocol
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