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Inactive state stabilized by the ECD and ECL1/3 In the GLP-1RFab7F38 structure, the saddle-like ECD loop S116-E127 covers the ECL1 helical region Q211-S219 that partially occupies the orthosteric ECD-binding site (Fig

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But used wisely, with resistance training, protein optimisation, and patient selection, they may represent the most significant advance in cardiometabolic medicine since statins